学术文献


  • Acylpyrogallols as Inhibitors of Antiapoptotic Bcl-2 Proteins. Journal of Medicinal Chemistry.
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  • Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges. Cold Spring Harbor Perspectives in Medicine.
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  • A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53. http://stke.sciencemag.org/.
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  • Discovery of 4‑((3′R,4′S,5′R)‑6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. Journal of Medicinal Chemistry.
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  • Reactivation of p53 by MDM2 Inhibitor MI-77301 for the Treatment of Endocrine-Resistant Breast Cancer. Molecular Cancer Therapeutics.
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  • Therapeutic Inhibition of the MDM2–p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas. Clinical Cancer Research.
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  • Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma. Clinical Cancer Research.
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  • TNFa-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38a MAPK Pathway. Cancer Cell.
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  • MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner. Neoplasia.
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  • Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo. Clinical Cancer Research.
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  • SAR405838: An Optimized Inhibitor of MDM2–p53 Interaction That Induces Complete and Durable Tumor Regression. Cancer Research.
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  • BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo. PLOS One.
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  • Smac Mimetics and Innate Immune Stimuli Synergize to Promote Tumor Death. Nature Biotechnology.
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  • A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53. Science Signaling.
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  • Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors. Journal of the American Chemical Society.
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  • A Potent and Highly Efficacious Bcl-2/Bcl-xL Inhibitor. Journal of Medicinal Chemistry.
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  • Structure-Based Design of Potent Bcl-2/Bcl-xL Inhibitors with Strong In Vivo Antitumor Activity. Journal of Medicinal Chemistry.
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  • Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold. Journal of Medicinal Chemistry.
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  • Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity. Journal of Medicinal Chemistry.
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  • Non-Peptidic and Potent Small-Molecule Inhibitors of cIAP-1/2 and XIAP Proteins. Journal of Medicinal Chemistry.
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  • MI-219-zinc Combination: A New Paradigm in MDM2 Inhibitor-Based Therapy. Oncogene.
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  • Cyclopeptide Smac Mimetics as Antagonists of IAP Proteins. Bioorganic & Medicinal Chemistry Letters.
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  • Potent and Orally Active Small-Molecule Inhibitors of the MDM2-p53 Interaction. Journal of Medicinal Chemistry.
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  • Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein. Biochemistry.
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  • Small Molecule Inhibitors of the MDM2-p53 Interaction Discovered by Ensemble-Based Receptor Models. Journal of the American Chemical Society.
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  • Therapeutic Window for Melanoma Treatment Provided by Selective Effects of the Proteasome on Bcl-2 Proteins. Cell Death and Differentiation.
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  • Pyrogallol-Based Molecules as Potent Inhibitors of the Antiapoptotic Bcl-2 Proteins. Journal of Medicinal Chemistry.
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  • Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins. Journal of Medicinal Chemistry.
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  • Antiangiogenic Effect of TW37, a Small-Molecule Inhibitor of Bcl-2. Cancer Research .
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  • Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors. Journal of the American Chemical Society.
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  • Bcl-2 Acts in a Proangiogenic Signaling Pathway through Nuclear, Factor-KB and CXC Chemokines. Cancer Research .
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  • Gossypol Acts Directly on the Mitochondria to Overcome Bcl-2- and Bcl-XL-Mediated Apoptosis Resistance. Molecular Cancer Therapeutics.
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  • Breast Cancer Cells Can Evade Apoptosis-Mediated Selective Killing by a Novel Small Molecule Inhibitor of Bcl-2. American Association for Cancer Research .
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  • Development and Optimization of a Binding Assay for the XIAP BIR3 Domain Using Fluorescence Polarization. Analytical Biochemistry.
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  • Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening. Journal of Medicinal Chemistry.
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  • Note: This is a select list of our scientific publications.